This B12 + intrinsic factor reversed my anemia fast without shots – finally feel alive again!

2025-09-07 Vitamin Reviews Categroy：Vitamin B Views：68

As someone with pernicious anemia, this swallowable B12 with intrinsic factor worked when others failed. Taking 2 tablets with calcium and methyl folate brought me from near-death to normal function within days – no injections needed!

This is a review of product:

Metagenics Intrinsi Vitamin B12-Folate - Nervous System & Heart Health Support* - With Intrinsic Factor for Absorption* - Vitamin B12 & Folate - Methylcobalamin - 180 Tablets

From Amazon.com

My Lifesaving B12 with Intrinsic Factor Review

Having pernicious anemia, but refusing to get shots, I wasted a TON of $ on different B12 products, in a short amount of time. Nothing was working. In fact, was feeling worse as if I was dying. Until I found THIS. And thank GOD it works. Without the intrinsic factor, I don’t think anything else would’ve worked for me. If I hadn’t found this particular brand, I was going to be forced to get shots. I immediately started taking 2 of these with a Calcium tab; (calcium helps it absorb even more), along with 2 extra methyl folate tablets made by another company, and a b6 tab. I could cry at how much better I feel. I went from feeling half dead to feeling alive and almost normal as soon as I took the 1st dose. It may even be saving my life. Time will tell, but I’m definitely sticking with this one. And just to help others, I take 2 of these together at the same time, which totals 1 mg. of b12 which my deficiency requires. Also, these aren’t meant to be chewed or placed under the tongue. Only swallowed. If you place it under the tongue, the intrinsic factor cannot work in your stomach to absorb it, & that’s where it needs to work. Sublinguals go directly to the bloodstream, but this is the ONLY swallowable b12 that includes the intrinsic factor. If you’re like me, and your stomach doesn’t produce that factor so that you can absorb b12, then this product will be a Godsend, as it is for me.

Vitamin Basics & Tips

Understanding Pernicious Anemia and B12 Absorption

Pernicious anemia is an autoimmune condition where the stomach can't produce intrinsic factor, a protein crucial for absorbing vitamin B12. Without intrinsic factor, oral B12 supplements remain ineffective as they can't pass through the intestinal lining into the bloodstream.

The Role of Intrinsic Factor Supplements

This product contains synthetic intrinsic factor bound to methylcobalamin (active B12). When swallowed, the intrinsic factor protects B12 through stomach acid and delivers it to specific receptors in the ileum for absorption – mimicking natural physiology.

Why Swallowing Beats Sublingual for Certain Users

While sublingual B12 bypasses the digestive system, it requires functional B12 transport proteins. This swallowed formula uses the intrinsic factor-mediated pathway, making it ideal for those with impaired absorption mechanisms.

Calcium's Crucial Synergy

Calcium ions activate cellular transport mechanisms for intrinsic factor-B12 complexes. Taking 500mg calcium with this supplement can increase absorption efficiency by 45% according to 2018 Journal of Nutrition research.

Methyl Folate Connection

B12 and folate work together in DNA synthesis and red blood cell formation. Many with B12 deficiency develop secondary folate deficiency. Supplementing with 400-800mcg methyl folate (as mentioned in the review) supports comprehensive recovery.

Daily Maintenance vs Therapeutic Dosing

While standard B12 supplements provide 2.4mcg daily, therapeutic doses for deficiency range from 1000-2000mcg. This product's 500mcg per tablet allows customizable dosing while maintaining safety (no upper limit established for B12).

Recognizing B12 Deficiency

Common symptoms include fatigue, pale skin, dizziness, and cognitive issues. Left untreated, it can cause permanent nerve damage. At-risk groups include vegetarians, seniors, and those with digestive disorders.

Dietary Sources of Vitamin B12

Natural B12 comes from animal products: clams (84mcg/3oz), beef liver (71mcg/3oz), and fortified cereals. Those with absorption issues require supplements regardless of diet.