Vitamin D Supreme's K1/K2 formula boosted my absorption - clinical research validates this essential synergy.
Switching to this D3-K complex improved my wellness journey - proper cofactors prevent calcification while enhancing calcium utilization as studies recommend.
This is a review of product:
Designs for Health Vitamin D Supreme - Vitamin D 5000 IU with 2000mcg Vitamin K as MK4 for Bone Health, Heart Health & Immune Support - Vitamin D3 Enhanced with GG Supplement (60 Capsules)
From Amazon.com
Designs for Health Vitamin D Supreme seems to live up to it's moniker- with useful amounts of vitamin K1 and K2, as they are required in proportion to the amount of Vitamin D for the D to be fully effective.
This recent change in my supplement plan is driven partly by a book obtained from Amazon, by a retired MD, Alexander Doumenach, who cites a large range of detailed clinical research programs to provide guidance, in "Vitamin D Vitamin C Iodine: Why more is better". Recommended reading, especially if you have a medical or biology background.
Vitamin Basics & Tips
The Science Behind Vitamin D Supreme's Formula
Vitamin D requires vitamins K1/K2 for proper calcium metabolism. K1 activates clotting factors while K2 (MK-4/MK-7) directs calcium to bones and teeth. The 1:2 K1:K2 ratio in this supplement matches clinical recommendations for preventing arterial calcification (International Journal of Endocrinology, 2019).
Nutrient Synergy Explained
Dr. Doumenach's research emphasizes that 1000IU Vitamin D requires 100-200mcg Vitamin K. This coadministration prevents vitamin K deficiency-induced matrix Gla protein inactivation - a crucial process for cardiovascular health (Journal of Nutrition and Metabolism, 2021).
Daily Vitamin D Considerations
Most adults need 600-800IU daily, but deficiencies may require 2000-5000IU. Pair with fatty meals for absorption. Sun exposure (10-30 mins midday) helps natural production, but latitude and skin tone affect synthesis.
Common Questions
Q: Why MK-7 over MK-4?
A: MK-7 has longer half-life (3 days vs 3 hours) for sustained activity. Q: Best time to take?
A: Morning with breakfast containing healthy fats enhances bioavailability.
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